Positive regulation of acute inflammatory response

Across TCGA patient cohorts, RNA activity of the Positive regulation of acute inflammatory response pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1_S351, SAMSN1_S23, and SASH3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of acute inflammatory response activity versus RCSD1_S351 in UCEC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RCSD1_S351 →	+0.670	+0.097	<.001	<.001	3	10
UCEC	SAMSN1_S23 →	+0.731	+0.086	<.001	<.001	3	10
OV	SASH3 →	+0.614	+0.073	<.001	<.001	3	10
GBM	SKAP2 →	+0.853	+0.143	<.001	<.001	3	10
OV	SPN →	+0.728	+0.066	<.001	<.001	3	10
UCEC	STK10 →	+0.453	+0.080	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002675 vs RCSD1_S351 — UCEC

Explore this scatter interactively →