Positive regulation of acute inflammatory response

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of acute inflammatory response pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 27 member genes.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher Positive regulation of acute inflammatory response pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and LUAD, show the opposite pattern, with higher activity associated with better survival.

SKCM, LUAD, and THYM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	II,III,IV	0.421	0.214	<.001	67	view →
LUAD	OS	Median	II,III,IV	0.734	0.472	<.001	56	view →
THYM	DFS	Tertile	All	0.553	0.882	.001	53	view →
KIRC	OS	Tertile	All	0.534	0.697	.001	52	view →
GBM	DFS	Median	All	0.171	0.332	<.001	36	view →
LGG	DFS	Median	All	0.294	0.457	<.001	36	view →
KIRP	DFS	Tertile	III,IV	0.362	0.841	.010	28	view →
THCA	DFS	Quartile	All	0.881	0.973	.004	18	view →
ESCA	DFS	Median	All	0.573	0.424	.017	13	view →
ACC	DFS	Median	II,III,IV	0.170	0.673	.017	12	view →
SARC	OS	Tertile	All	0.760	0.454	.007	9	view →
PCPG	DFS	Tertile	All	0.612	0.967	.012	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0002675–SKCM (OS)

Open the SKCM breakdown →