Positive regulation of acute inflammatory response

Across TCGA cell cohorts, RNA activity of the Positive regulation of acute inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CITED1, MDH2, and CCDC71, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of acute inflammatory response activity versus CITED1 in SKIN (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CITED1 →	+2.738	+0.203	.001	.003	3	5
SKIN	MDH2 →	+1.045	+0.193	.002	.003	3	5
OESOPHAGUS	CCDC71 →	+1.139	+0.362	.007	.006	3	4
LIVER	PRTG →	+2.956	+0.268	<.001	.008	3	4
LIVER	KCNG3 →	+0.450	+0.268	.003	.008	3	4
LARGE_INTESTINE	CLPP →	+1.101	+0.310	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002675 vs CITED1 — SKIN

Explore this scatter interactively →