Somatic diversification of immune receptors via somatic mutation

Across TCGA patient cohorts, RNA activity of the Somatic diversification of immune receptors via somatic mutation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LIG1, TOP2A, and TPX2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Somatic diversification of immune receptors via somatic mutation activity versus LIG1 in HNSC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LIG1 →	+0.569	+0.089	<.001	<.001	3	9
LUAD	TOP2A →	+1.134	+0.116	<.001	<.001	3	9
LUAD	TPX2 →	+0.920	+0.107	<.001	<.001	3	9
GBM	CBX3 →	+0.460	+0.088	<.001	<.001	3	9
LUAD	CCNA2 →	+0.865	+0.112	<.001	<.001	3	9
LSCC	GTF3C4 →	+0.480	+0.101	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002566 vs LIG1 — HNSC

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