Somatic diversification of immune receptors via somatic mutation

Across TCGA pan-cancer cohorts, RNA activity of the Somatic diversification of immune receptors via somatic mutation pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 13 member genes.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher Somatic diversification of immune receptors via somatic mutation pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LGG and UCS, show the opposite pattern, with higher activity associated with better survival.

UCEC, LGG, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.772	0.895	<.001	84	view →
LGG	DFS	Median	All	0.823	0.656	<.001	49	view →
ACC	DFS	Median	IV	0.048	0.380	<.001	46	view →
UCS	OS	Median	IV	0.732	0.224	.018	36	view →
BRCA	DFS	Tertile	III,IV	0.947	0.831	.002	21	view →
HNSC	DFS	Quartile	IV	0.821	0.379	.003	16	view →
CHOL	DFS	Tertile	All	0.809	0.165	.010	12	view →
COAD	OS	Quartile	II,III,IV	0.628	0.853	.010	12	view →
MESO	DFS	Tertile	III,IV	0.149	0.585	.023	9	view →
SARC	OS	Tertile	All	0.402	0.643	.014	7	view →
LUAD	OS	Quartile	III,IV	0.497	0.783	.022	7	view →
READ	DFS	Tertile	IV	0.234	1.000	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0002566–UCEC (DFS)

Open the UCEC breakdown →