Somatic diversification of immune receptors via somatic mutation

Across TCGA cell cohorts, RNA activity of the Somatic diversification of immune receptors via somatic mutation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRRAP, POLR2A, and CLASP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Somatic diversification of immune receptors via somatic mutation activity versus TRRAP in OVARY (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TRRAP →	+0.706	+0.852	.002	.006	3	6
OVARY	POLR2A →	+0.903	+0.606	<.001	.009	3	5
BONE	CLASP1 →	+0.994	+1.509	.003	<.001	2	6
BLOOD_Lymphoma	HILPDA →	+1.014	+1.088	.008	<.001	3	4
LUNG_NSCLC_LUAD	METTL2B →	+0.586	+0.932	.005	.003	3	4
OVARY	SNRNP200 →	+0.421	+0.693	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002566 vs TRRAP — OVARY

Explore this scatter interactively →