Mast cell chemotaxis

Across TCGA cell cohorts, RNA activity of the Mast cell chemotaxis pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC6A7, UBQLN2, and USP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC6A7 grouped by Mast cell chemotaxis-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SLC6A7 →	-0.205	-1.290	.003	<.001	3	4
LIVER	UBQLN2 →	-0.323	-1.639	.006	<.001	2	5
OESOPHAGUS	USP3 →	+0.106	+0.097	.007	.002	2	4
OESOPHAGUS	NUDT4 →	-0.132	-0.144	<.001	<.001	3	3
OVARY	SCYL1 →	-0.176	-1.069	.001	.005	3	3
OVARY	PPP1R15B →	-0.265	-1.115	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC6A7 by Mast cell chemotaxis activity — OVARY

Explore this box plot interactively →