Mast cell chemotaxis

Across TCGA pan-cancer cohorts, RNA activity of the Mast cell chemotaxis pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 11 member genes.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher Mast cell chemotaxis pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and UCEC, show the opposite pattern, with higher activity associated with better survival.

SKCM, UCEC, and STAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	III,IV	0.946	0.719	<.001	49	view →
UCEC	DFS	Tertile	IV	0.782	0.206	<.001	36	view →
STAD	OS	Median	All	0.478	0.639	.006	36	view →
OV	OS	Median	All	0.274	0.354	.006	30	view →
ESCA	DFS	Quartile	III,IV	0.567	0.250	.003	26	view →
KIRP	DFS	Median	All	0.796	0.979	.008	24	view →
THYM	DFS	Tertile	II,III,IV	1.000	0.782	.003	22	view →
UVM	DFS	Quartile	All	0.468	0.878	.009	17	view →
CHOL	DFS	Tertile	II,III,IV	0.754	0.131	.003	17	view →
READ	DFS	Tertile	III,IV	0.413	0.969	<.001	16	view →
COAD	DFS	Tertile	IV	0.189	0.460	.011	14	view →
DLBC	OS	Median	All	0.553	0.952	.026	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0002551–SKCM (OS)

Open the SKCM breakdown →