Acute inflammatory response

Across TCGA patient cohorts, RNA activity of the Acute inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCGR2A, PELATON, and MIR223HG, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acute inflammatory response activity versus FCGR2A in OV (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FCGR2A →	+0.996	+0.215	.002	<.001	3	9
GBM	PELATON →	+0.804	+0.184	<.001	<.001	3	9
LSCC	MIR223HG →	+1.238	+0.192	<.001	<.001	3	9
CCRCC	CR1 →	+1.013	+0.180	<.001	<.001	3	9
GBM	PLEK →	+1.239	+0.220	<.001	<.001	3	9
GBM	LILRA6 →	+0.918	+0.218	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002526 vs FCGR2A — OV

Explore this scatter interactively →