Leukocyte migration involved in inflammatory response

Across TCGA patient cohorts, RNA activity of the Leukocyte migration involved in inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBMS1, LINC01638, and ANKRD6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukocyte migration involved in inflammatory response activity versus RBMS1 in BRCA (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RBMS1 →	+0.532	+0.145	<.001	.001	3	7
COAD	LINC01638 →	+0.270	+0.102	.004	.007	3	7
LSCC	ANKRD6 →	+0.443	+0.087	.003	.009	3	6
UCEC	TRPC1 →	+0.963	+0.147	<.001	<.001	3	6
UCEC	DIPK2B →	+0.655	+0.168	<.001	<.001	3	6
COAD	ITGA5 →	+0.957	+0.171	.003	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002523 vs RBMS1 — BRCA

Explore this scatter interactively →