Leukocyte migration involved in inflammatory response

Across TCGA pan-cancer cohorts, RNA activity of the Leukocyte migration involved in inflammatory response pathway is associated with patient survival in 27 of 34 cancer lineages. Pathway activity is summarized from the expression of its 19 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Leukocyte migration involved in inflammatory response pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRP and CESC, show the opposite pattern, with higher activity associated with better survival.

KIRC, KIRP, and BRCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.519	0.715	<.001	124	view →
KIRP	OS	Median	II,III,IV	0.901	0.615	.001	70	view →
BRCA	OS	Tertile	III,IV	0.737	0.905	<.001	47	view →
MESO	OS	Quartile	All	0.233	0.493	.008	47	view →
ACC	DFS	Median	II,III,IV	0.206	0.593	<.001	42	view →
UCEC	OS	Median	All	0.899	0.950	.002	36	view →
CESC	OS	Median	IV	0.588	0.095	.007	30	view →
SKCM	OS	Tertile	All	0.410	0.255	.001	26	view →
SCLC	DFS	Tertile	II,III,IV	0.329	1.000	.006	21	view →
UVM	DFS	Quartile	II,III,IV	0.375	0.651	.011	20	view →
STAD	DFS	Median	IV	0.689	0.216	.024	17	view →
THCA	DFS	Median	III,IV	0.585	0.861	.005	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GO:0002523–KIRC (DFS)

Open the KIRC breakdown →