Leukocyte migration involved in inflammatory response

Across TCGA pan-cancer cohorts, RNA activity of the Leukocyte migration involved in inflammatory response pathway differs between tumor and matched normal tissue in 7 of the 18 cancer types tested.

The strongest signal is observed in thyroid carcinoma (THCA), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KICH and PAAD, show the opposite pattern, with lower activity in tumor tissue.

THCA, KIRC, and KICH show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
THCA	Female	III,IV	+0.077	<.001	11	view →
KIRC	Male	All	+0.050	<.001	10	view →
KICH	All	II,III,IV	−0.049	.005	5	view →
PAAD	Male	All	−0.074	.004	4	view →
BRCA	All	IV	−0.084	.042	2	view →
KIRP	All	All	+0.031	.015	2	view →
LUAD	All	All	−0.023	.040	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 7 strongest of 7 lineages.

GO:0002523–THCA

Open the THCA breakdown →