Leukocyte migration involved in inflammatory response

Across TCGA cell cohorts, RNA activity of the Leukocyte migration involved in inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZC4H2, SLC15A2, and BAALC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukocyte migration involved in inflammatory response activity versus ZC4H2 in BLOOD_Leukemia (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZC4H2 →	-2.524	-0.598	.001	<.001	3	4
BLOOD_Leukemia	SLC15A2 →	+1.360	+0.520	<.001	<.001	3	3
OVARY	BAALC →	+0.347	+0.324	.005	.006	3	3
SKIN	ZNF687 →	-0.910	-0.310	<.001	.001	3	3
LUNG_NSCLC_LUAD	VPS45 →	-0.942	-0.421	.003	<.001	3	3
BLOOD_Leukemia	ZIK1 →	-2.985	-0.516	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002523 vs ZC4H2 — BLOOD_Leukemia

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