Lymphoid progenitor cell differentiation

Across TCGA patient cohorts, RNA activity of the Lymphoid progenitor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADGRE3, NALCN, and NDNF, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymphoid progenitor cell differentiation activity versus ADGRE3 in PDAC (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ADGRE3 →	+0.819	+0.576	<.001	<.001	3	3
BRCA	NALCN →	-0.270	-0.660	.001	.002	3	3
BRCA	NDNF →	-0.752	-0.604	.001	<.001	3	3
BRCA	SCAT2 →	+0.530	+0.777	<.001	.003	3	3
LUAD	TNFRSF1B →	+0.431	+0.390	.002	.009	3	3
HNSC	E2F3-IT1 →	+0.625	+0.366	.009	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002320 vs ADGRE3 — PDAC

Explore this scatter interactively →