Lymphoid progenitor cell differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Lymphoid progenitor cell differentiation pathway differs between tumor and matched normal tissue in 12 of the 18 cancer types tested.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KIRC and LUSC, show the opposite pattern, with lower activity in tumor tissue.

KIRC, LUSC, and LUAD show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KIRC	All	IV	−0.054	<.001	12	view →
LUSC	All	III,IV	−0.081	<.001	9	view →
LUAD	Female	III,IV	−0.067	<.001	7	view →
BLCA	All	All	−0.063	.001	7	view →
BRCA	All	III,IV	−0.065	<.001	6	view →
THCA	All	All	−0.032	<.001	5	view →
PRAD	All	All	−0.044	<.001	2	view →
UCEC	All	All	−0.033	.011	2	view →
KIRP	All	All	−0.025	.008	2	view →
HNSC	All	II,III,IV	−0.021	.037	2	view →
KICH	All	All	−0.023	.039	1	view →
LIHC	All	II,III,IV	+0.021	.036	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 12 lineages.

GO:0002320–KIRC

Open the KIRC breakdown →