T cell activation involved in immune response

Across TCGA cell cohorts, RNA activity of the T cell activation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPS14, CSNK1G2, and DTD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell activation involved in immune response activity versus MRPS14 in BONE (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MRPS14 →	+0.425	+0.420	.004	.001	3	5
SOFT_TISSUE	CSNK1G2 →	+0.852	+0.248	.006	.005	2	6
UPPER_AERODIGESTIVE_TRACT	DTD2 →	+1.137	+0.628	.006	.001	3	5
LIVER	CLUH →	+1.031	+0.436	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	UQCRC1 →	+0.905	+0.535	.005	.007	3	5
UPPER_AERODIGESTIVE_TRACT	PECR →	+1.086	+0.532	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002286 vs MRPS14 — BONE

Explore this scatter interactively →