T cell activation involved in immune response

Across TCGA pan-cancer cohorts, RNA activity of the T cell activation involved in immune response pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 123 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher T cell activation involved in immune response pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and SKCM, show the opposite pattern, with higher activity associated with better survival.

HNSC, SKCM, and LUAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.754	0.642	<.001	136	view →
SKCM	OS	Median	All	0.451	0.263	<.001	95	view →
LUAD	OS	Tertile	II,III,IV	0.704	0.321	<.001	92	view →
CESC	DFS	Tertile	All	0.856	0.644	<.001	82	view →
ACC	OS	Tertile	All	0.697	1.000	<.001	61	view →
LIHC	DFS	Median	III,IV	0.344	0.093	.009	32	view →
LGG	DFS	Tertile	All	0.295	0.465	<.001	32	view →
GBM	DFS	Quartile	All	0.133	0.259	<.001	29	view →
PAAD	OS	Median	II,III,IV	0.681	0.497	.003	29	view →
LAML	DFS	Quartile	All	0.244	0.547	.001	28	view →
UCEC	DFS	Quartile	II,III,IV	0.730	0.260	.019	26	view →
CHOL	DFS	Tertile	All	0.732	0.239	.011	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0002286–HNSC (DFS)

Open the HNSC breakdown →