Neutrophil activation involved in immune response

Across TCGA cell cohorts, RNA activity of the Neutrophil activation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APLP1, UBA6, and RDH10, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, APLP1 grouped by Neutrophil activation involved in immune response-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	APLP1 →	-1.968	-1.151	<.001	<.001	3	3
PANCREAS	UBA6 →	-0.802	-0.998	.003	.007	3	3
OVARY	RDH10 →	-1.971	-0.849	.006	.008	3	3
BLOOD_Myeloma	ZNF85 →	-1.576	-1.293	.002	.003	3	3
BLOOD_Myeloma	LRPAP1 →	-1.080	-1.104	.002	.001	3	3
KIDNEY	POLR2J2 →	+0.885	+1.246	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

APLP1 by Neutrophil activation involved in immune response activity — SKIN

Explore this box plot interactively →