Innate immune response in mucosa

Across TCGA patient cohorts, RNA activity of the Innate immune response in mucosa pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRP36_S73, RFC4, and ECT2_T359, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Innate immune response in mucosa activity versus RRP36_S73 in LSCC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RRP36_S73 →	+0.962	+0.122	<.001	<.001	3	7
LSCC	RFC4 →	+0.568	+0.111	<.001	<.001	3	7
LUAD	ECT2_T359 →	+1.240	+0.102	<.001	<.001	3	6
LSCC	TIMELESS_S1173 →	+0.903	+0.112	<.001	<.001	3	6
GBM	TOP2A_S1377 →	+0.889	+0.143	<.001	<.001	3	6
GBM	UBTF_S484 →	+0.904	+0.121	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002227 vs RRP36_S73 — LSCC

Explore this scatter interactively →