Innate immune response activating cell surface receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Innate immune response activating cell surface receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF517, GCC2, and UQCR11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF517 grouped by Innate immune response activating cell surface receptor signaling pathway-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZNF517 →	-0.523	-0.426	<.001	.009	3	4
LIVER	GCC2 →	+0.689	+0.287	.006	.002	3	3
CNS	UQCR11 →	-0.575	-0.541	.004	.008	3	3
CNS	DENND4C →	-0.553	-0.696	.001	.006	3	3
CNS	VPREB1 →	-0.117	-0.732	.007	<.001	3	3
BLOOD_Myeloma	ENO2 →	-3.043	-0.265	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF517 by Innate immune response activating cell surface receptor signaling pathway activity — BLOOD_Leukemia

Explore this box plot interactively →