Innate immune response activating cell surface receptor signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Innate immune response activating cell surface receptor signaling pathway pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 90 member genes.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher Innate immune response activating cell surface receptor signaling pathway pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and HNSC, show the opposite pattern, with higher activity associated with better survival.

SKCM, HNSC, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.446	0.286	<.001	75	view →
HNSC	OS	Median	IV	0.478	0.250	<.001	51	view →
LGG	OS	Median	All	0.755	0.864	<.001	45	view →
UCEC	DFS	Median	All	0.785	0.879	<.001	38	view →
CESC	DFS	Median	All	0.885	0.776	.001	36	view →
LUAD	DFS	Tertile	All	0.737	0.614	.009	30	view →
LAML	DFS	Quartile	All	0.379	0.801	.001	28	view →
ACC	OS	Tertile	II,III,IV	0.868	0.612	.016	25	view →
ESCA	DFS	Tertile	III,IV	0.542	0.207	.006	21	view →
KIRP	OS	Median	IV	0.042	0.523	.015	21	view →
TGCT	OS	Median	All	0.885	1.000	.010	18	view →
GBM	DFS	Median	All	0.152	0.247	.001	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0002220–SKCM (OS)

Open the SKCM breakdown →