Thyroid hormone mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Thyroid hormone mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR74, CRNKL1, and C15orf61, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thyroid hormone mediated signaling pathway activity versus WDR74 in OV (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	WDR74 →	+0.477	+0.196	<.001	.003	3	4
LSCC	CRNKL1 →	+0.427	+0.575	.001	.002	3	4
LSCC	C15orf61 →	+0.311	+0.597	<.001	<.001	3	4
LSCC	TRIT1 →	+0.469	+0.622	.002	<.001	3	4
LSCC	MCM2 →	+0.921	+0.787	<.001	<.001	3	4
LSCC	EIF3E →	+0.439	+0.805	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002154 vs WDR74 — OV

Explore this scatter interactively →