tRNA wobble base modification

Across TCGA patient cohorts, RNA activity of the tRNA wobble base modification pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCBP1, NASP, and RFC4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA wobble base modification activity versus NCBP1 in GBM (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NCBP1 →	+0.246	+0.032	.009	.004	3	7
BRCA	NASP →	+0.446	+0.019	<.001	<.001	3	6
HNSC	RFC4 →	+0.462	+0.061	<.001	<.001	3	6
LSCC	SMARCA4 →	+0.307	+0.037	<.001	<.001	3	6
GBM	SSRP1 →	+0.479	+0.037	.005	.002	3	6
LSCC	SUPT16H →	+0.324	+0.039	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002097 vs NCBP1 — GBM

Explore this scatter interactively →