Regulation of receptor internalization

Across TCGA cell cohorts, RNA activity of the Regulation of receptor internalization pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARRB2, HSPD1, and SHPK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of receptor internalization activity versus ARRB2 in SKIN (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ARRB2 →	-0.789	-0.166	<.001	.009	3	6
PANCREAS	HSPD1 →	-0.807	-0.365	.003	<.001	3	6
BLOOD_Myeloma	SHPK →	-1.162	-1.844	.007	<.001	3	5
LARGE_INTESTINE	EPS8L1 →	+1.777	+0.518	<.001	.004	3	5
PANCREAS	RABEP1 →	-0.887	-0.321	.002	<.001	3	5
URINARY_TRACT	MYBBP1A →	-1.159	-0.291	.008	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002090 vs ARRB2 — SKIN

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