Columnar/cuboidal epithelial cell development

Across TCGA patient cohorts, RNA activity of the Columnar/cuboidal epithelial cell development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLIT3, SERPINF2, and DNAJC7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Columnar/cuboidal epithelial cell development activity versus SLIT3 in BRCA (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLIT3 →	+0.616	+0.032	<.001	<.001	3	6
BRCA	SERPINF2 →	+0.640	+0.029	<.001	<.001	3	6
BRCA	DNAJC7 →	-0.418	-0.040	<.001	<.001	3	6
HNSC	VDAC1 →	-0.259	-0.039	<.001	.003	3	6
BRCA	FKBP7 →	+0.473	+0.029	<.001	<.001	3	5
BRCA	OLFML3 →	+1.072	+0.032	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002066 vs SLIT3 — BRCA

Explore this scatter interactively →