Columnar/cuboidal epithelial cell development

Across TCGA pan-cancer cohorts, RNA activity of the Columnar/cuboidal epithelial cell development pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 50 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Columnar/cuboidal epithelial cell development pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and HNSC, show the opposite pattern, with higher activity associated with better survival.

ACC, DLBC, and UCS are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	III,IV	0.192	0.695	.002	59	view →
DLBC	DFS	Quartile	All	0.516	1.000	.010	30	view →
UCS	DFS	Tertile	IV	0.855	0.250	.024	24	view →
HNSC	DFS	Median	III,IV	0.663	0.526	.006	16	view →
THCA	DFS	Median	All	0.971	0.911	.005	14	view →
THYM	DFS	Median	II,III,IV	0.971	0.839	.010	13	view →
READ	DFS	Median	IV	0.253	0.704	.007	13	view →
SCLC	DFS	Median	II,III,IV	0.791	0.232	.007	12	view →
LUAD	DFS	Tertile	IV	0.174	1.000	.026	12	view →
ESCA	OS	Quartile	IV	0.206	0.856	.038	12	view →
MESO	OS	Tertile	All	0.251	0.673	.024	11	view →
LIHC	DFS	Tertile	All	0.482	0.632	.020	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0002066–ACC (DFS)

Open the ACC breakdown →