Columnar/cuboidal epithelial cell development

Across TCGA patient cohorts, RNA activity of the Columnar/cuboidal epithelial cell development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPBG, PTBP1P, and PMP22, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Columnar/cuboidal epithelial cell development activity versus TPBG in BRCA (Pearson r = 0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TPBG →	+0.845	+0.414	<.001	.005	3	4
UCEC	PTBP1P →	-0.321	-0.109	.005	.001	3	4
BRCA	PMP22 →	+0.680	+0.572	.008	<.001	3	3
PDAC	SLAIN2 →	+0.186	+0.245	.001	.005	3	3
PDAC	GBE1 →	+0.355	+0.252	<.001	.004	3	3
PDAC	DAD1 →	+0.281	+0.350	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002066 vs TPBG — BRCA

Explore this scatter interactively →