Columnar/cuboidal epithelial cell development

Across TCGA cell cohorts, RNA activity of the Columnar/cuboidal epithelial cell development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HDAC1, PCMT1, and FAM126A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HDAC1 grouped by Columnar/cuboidal epithelial cell development-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	HDAC1 →	-0.932	-1.923	.005	<.001	2	5
BLOOD_Lymphoma	PCMT1 →	-0.473	-1.861	.008	<.001	3	4
OESOPHAGUS	FAM126A →	-1.468	-0.331	.001	<.001	3	4
CNS	GON7 →	-0.528	-0.735	.001	.007	3	4
PANCREAS	YPEL2 →	+0.901	+0.994	.005	.005	3	4
BONE	NOB1 →	-0.774	-1.548	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HDAC1 by Columnar/cuboidal epithelial cell development activity — BLOOD_Lymphoma

Explore this box plot interactively →