Columnar/cuboidal epithelial cell development

Across TCGA cell cohorts, RNA activity of the Columnar/cuboidal epithelial cell development pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EI24, PDHB, and CDC20, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Columnar/cuboidal epithelial cell development activity versus EI24 in BREAST (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	EI24 →	+1.182	+0.370	.006	.003	3	3
BREAST	PDHB →	+1.335	+0.349	.007	.006	3	3
LARGE_INTESTINE	CDC20 →	+1.271	+1.663	.004	.001	3	3
LARGE_INTESTINE	NGLY1 →	+0.774	+1.663	.004	.001	3	3
LARGE_INTESTINE	MRPL39 →	+0.855	+1.663	.001	.001	3	3
LARGE_INTESTINE	CCT8 →	+1.093	+1.663	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002066 vs EI24 — BREAST

Explore this scatter interactively →