Columnar/cuboidal epithelial cell differentiation

Across TCGA patient cohorts, RNA activity of the Columnar/cuboidal epithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP1B, SPOCK1, and ARHGEF25, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Columnar/cuboidal epithelial cell differentiation activity versus MAP1B in LSCC (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1B →	+2.152	+0.507	<.001	<.001	3	9
CCRCC	SPOCK1 →	+1.513	+0.450	.002	.001	3	6
CCRCC	ARHGEF25 →	+0.547	+0.414	<.001	<.001	2	7
LSCC	KLHL42 →	+0.694	+0.296	<.001	<.001	3	6
BRCA	TGFB1I1 →	+0.757	+0.604	.002	<.001	3	6
OV	CALD1 →	+0.959	+0.769	.004	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002065 vs MAP1B — LSCC

Explore this scatter interactively →