Columnar/cuboidal epithelial cell differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Columnar/cuboidal epithelial cell differentiation pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 120 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Columnar/cuboidal epithelial cell differentiation pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and BRCA, show the opposite pattern, with higher activity associated with better survival.

HNSC, BRCA, and LUAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.710	0.465	.004	90	view →
BRCA	OS	Median	All	0.950	0.907	.007	38	view →
LUAD	DFS	Median	IV	0.327	0.620	.014	24	view →
ACC	OS	Median	III,IV	0.186	0.751	.005	20	view →
MESO	OS	Quartile	II,III,IV	0.283	0.499	.024	14	view →
THCA	OS	Quartile	II,III,IV	0.798	1.000	.004	12	view →
DLBC	DFS	Median	II,III,IV	0.580	1.000	.013	10	view →
STAD	DFS	Quartile	II,III,IV	0.222	0.637	.036	9	view →
ESCA	OS	Median	III,IV	0.559	0.351	.019	8	view →
LAML	DFS	Tertile	All	0.226	0.534	.025	6	view →
READ	DFS	Tertile	IV	0.206	0.707	.039	6	view →
TGCT	DFS	Median	All	0.578	0.756	.031	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0002065–HNSC (DFS)

Open the HNSC breakdown →