Endothelial cell proliferation

Across TCGA cell cohorts, RNA activity of the Endothelial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CASK, SNAPC2, and PLCG2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endothelial cell proliferation activity versus CASK in PANCREAS (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CASK →	+1.105	+0.215	.004	.007	3	5
LUNG_SCLC	SNAPC2 →	-1.015	-0.216	.003	.007	3	5
BLOOD_Lymphoma	PLCG2 →	+3.202	+0.187	.001	.001	3	4
PANCREAS	SPIN4 →	+0.969	+0.266	.005	<.001	3	4
STOMACH	ZNF555 →	+1.362	+0.354	.003	.001	3	4
BONE	PIP4P1 →	+0.890	+0.401	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001935 vs CASK — PANCREAS

Explore this scatter interactively →