Positive regulation of receptor recycling

Across TCGA patient cohorts, RNA activity of the Positive regulation of receptor recycling pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CSE1L, ANK2_S3765, and INPP5D_S243, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of receptor recycling activity versus CSE1L in GBM (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CSE1L →	-0.298	-0.071	<.001	<.001	3	7
LSCC	ANK2_S3765 →	+0.992	+0.088	<.001	<.001	3	6
LSCC	INPP5D_S243 →	+0.799	+0.076	<.001	<.001	3	6
LSCC	LSP1_S252 →	+0.425	+0.046	<.001	<.001	3	6
LSCC	NFATC2 →	+0.290	+0.057	<.001	<.001	3	6
PDAC	SAMHD1 →	+0.300	+0.049	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001921 vs CSE1L — GBM

Explore this scatter interactively →