Regulation of receptor recycling

Across TCGA cell cohorts, RNA activity of the Regulation of receptor recycling pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB21, ASB8, and KPNA1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB21 grouped by Regulation of receptor recycling-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RAB21 →	-0.688	-0.440	<.001	<.001	3	3
OVARY	ASB8 →	-0.482	-0.576	<.001	.005	3	3
CNS	KPNA1 →	-0.503	-0.639	<.001	.009	3	3
BLOOD_Leukemia	C2CD2L →	-0.740	-0.576	.002	.008	3	3
SKIN	SLFN12 →	-0.978	-0.715	.002	.006	3	3
BREAST	FYN →	+2.367	+0.737	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB21 by Regulation of receptor recycling activity — URINARY_TRACT

Explore this box plot interactively →