Regulation of receptor recycling

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of receptor recycling pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 25 member genes.

The strongest signal is observed in thyroid carcinoma (THCA), where higher Regulation of receptor recycling pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ESCA and SCLC, show the opposite pattern, with higher activity associated with better survival.

THCA, ESCA, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Tertile	II,III,IV	0.225	0.901	<.001	78	view →
ESCA	OS	Median	III,IV	0.635	0.319	.001	40	view →
UVM	DFS	Quartile	III,IV	0.312	0.910	.016	24	view →
SCLC	OS	Tertile	III,IV	0.684	0.299	.006	20	view →
KIRP	OS	Median	All	0.952	0.544	<.001	18	view →
ACC	OS	Median	II,III,IV	0.934	0.786	.011	15	view →
SKCM	DFS	Tertile	All	0.225	0.155	.011	13	view →
LUSC	OS	Median	IV	0.057	0.786	.008	12	view →
MESO	DFS	Median	II,III,IV	0.249	0.562	.009	12	view →
KIRC	DFS	Quartile	III,IV	0.325	0.557	.009	10	view →
GBM	OS	Quartile	All	0.217	0.344	.018	9	view →
LAML	DFS	Tertile	All	0.270	0.505	.023	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0001919–THCA (DFS)

Open the THCA breakdown →