Regulation of receptor recycling

Across TCGA cell cohorts, RNA activity of the Regulation of receptor recycling pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMC2, PDP2, and CNNM1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of receptor recycling activity versus LAMC2 in KIDNEY (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	LAMC2 →	+4.635	+0.364	.004	.009	3	6
BONE	PDP2 →	-1.151	-0.234	.003	.001	3	5
STOMACH	CNNM1 →	-1.619	-0.326	<.001	<.001	3	4
OESOPHAGUS	RNF2 →	+0.994	+0.393	<.001	<.001	3	4
SOFT_TISSUE	C1orf115 →	-1.502	-0.208	.002	<.001	3	4
LUNG_SCLC	UQCRB →	+0.544	+0.160	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001919 vs LAMC2 — KIDNEY

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