Endothelial cell development

Across TCGA patient cohorts, RNA activity of the Endothelial cell development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HELZ_S1317, SLC39A10, and SYNPO_S525, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endothelial cell development activity versus HELZ_S1317 in OV (Pearson r = 0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HELZ_S1317 →	-0.692	-0.528	<.001	.001	3	3
HNSC	SLC39A10 →	+0.256	+0.376	.002	<.001	3	2
LSCC	SYNPO_S525 →	-0.352	-0.134	.001	.001	3	2
OV	CCDC97_S212 →	-1.012	-0.260	.002	<.001	3	2
BRCA	FARSA_S301 →	-1.211	-0.272	<.001	<.001	3	2
BRCA	MSH6_S830 →	-0.904	-0.263	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001885 vs HELZ_S1317 — OV

Explore this scatter interactively →