Blastocyst development

Across TCGA patient cohorts, RNA activity of the Blastocyst development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are XPO5, RRP36_S73, and SMC2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Blastocyst development activity versus XPO5 in LSCC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	XPO5 →	+0.531	+0.041	<.001	<.001	3	9
UCEC	RRP36_S73 →	+0.933	+0.076	<.001	<.001	3	8
UCEC	SMC2 →	+0.706	+0.069	<.001	<.001	3	8
LSCC	SMC4 →	+0.510	+0.044	<.001	<.001	3	8
LUAD	TOP2A_S1247 →	+1.195	+0.042	<.001	<.001	3	8
LUAD	CDK1 →	+0.732	+0.040	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001824 vs XPO5 — LSCC

Explore this scatter interactively →