Fatty acid alpha-oxidation

Across TCGA cell cohorts, RNA activity of the Fatty acid alpha-oxidation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCC, SH2B3, and GOT1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MCC grouped by Fatty acid alpha-oxidation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MCC →	+1.992	+1.490	.003	.003	3	4
KIDNEY	SH2B3 →	-1.102	-1.440	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	GOT1 →	+0.910	+1.356	.001	.004	3	4
OVARY	C12orf57 →	+0.912	+1.068	.002	.008	3	4
STOMACH	MX1 →	-2.645	-1.244	<.001	.001	3	4
LUNG_SCLC	YIPF6 →	+0.731	+1.438	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MCC by Fatty acid alpha-oxidation activity — BONE

Explore this box plot interactively →