Fatty acid alpha-oxidation

Across TCGA cell cohorts, RNA activity of the Fatty acid alpha-oxidation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRRF, ZNF518B, and OLFM2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid alpha-oxidation activity versus MRRF in OESOPHAGUS (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MRRF →	+0.633	+0.318	.007	.006	3	2
OESOPHAGUS	ZNF518B →	-2.308	-0.366	<.001	.003	3	2
LUNG_SCLC	OLFM2 →	+3.786	+0.547	.005	.009	2	3
LUNG_SCLC	ZNF782 →	+0.724	+0.550	.002	.002	2	3
LUNG_SCLC	MCIDAS →	+1.357	+0.550	.004	.002	3	2
BLOOD_Leukemia	SH2D4A →	+2.010	+0.373	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001561 vs MRRF — OESOPHAGUS

Explore this scatter interactively →