Antral ovarian follicle growth

Across TCGA patient cohorts, RNA activity of the Antral ovarian follicle growth pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATP5F1C, NFATC4, and RILPL1_S346, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antral ovarian follicle growth activity versus ATP5F1C in LSCC (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ATP5F1C →	-0.281	-0.071	.002	<.001	3	5
LSCC	NFATC4 →	+0.341	+0.062	<.001	<.001	3	5
LSCC	RILPL1_S346 →	+0.539	+0.075	.001	<.001	2	6
LSCC	ATP5F1B →	-0.259	-0.078	.002	<.001	3	5
PDAC	F11R →	-0.390	-0.053	.002	.001	3	5
GBM	STK17A →	+0.394	+0.066	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001547 vs ATP5F1C — LSCC

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