Response to acid chemical

Across TCGA cell cohorts, RNA activity of the Response to acid chemical pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RALB, C1GALT1C1, and MVP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to acid chemical activity versus RALB in LIVER (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RALB →	+1.310	+0.147	.005	.006	3	7
BLOOD_Leukemia	C1GALT1C1 →	+0.434	+0.090	.003	.006	3	7
BLOOD_Lymphoma	MVP →	+2.219	+0.148	.002	.001	2	6
LUNG_NSCLC_LUAD	ALDH3B1 →	+1.915	+0.135	.003	.001	3	5
BONE	RNF103 →	-1.052	-0.180	.002	.001	3	4
OVARY	POLK →	+1.054	+0.209	.008	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001101 vs RALB — LIVER

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