Regulation of mitochondrial RNA catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of mitochondrial RNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF2AK2, CAV1, and IFIT2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EIF2AK2 grouped by Regulation of mitochondrial RNA catabolic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	EIF2AK2 →	-0.868	-0.171	<.001	<.001	3	7
BREAST	CAV1 →	-2.857	-0.153	<.001	<.001	3	4
BREAST	IFIT2 →	-1.499	-0.169	.004	.006	3	4
BREAST	PMAIP1 →	-1.807	-0.131	.002	.004	3	4
SOFT_TISSUE	GPR176 →	-1.921	-0.261	.005	.008	3	4
BREAST	C1QTNF1 →	-1.773	-0.185	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EIF2AK2 by Regulation of mitochondrial RNA catabolic process activity — LIVER

Explore this box plot interactively →