Regulation of glutamine family amino acid metabolic process

pathway activity — cross-omics
GO:0000820Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Regulation of glutamine family amino acid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATP1A1_S16, ATP2B4_S328, and XRCC1_S461, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADATP1A1_S16 →+1.002+0.742<.001<.00134
UCECATP2B4_S328 →+0.851+0.655<.001<.00134
OVXRCC1_S461 →-0.974-0.679<.001<.00134
UCECSLC43A1_S237 →+1.315+1.072.006.00324
BRCAATP2B4_S13 →+0.846+1.103<.001<.00124
GBMACTR8_S132 →-0.304-0.550<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration