Telomere maintenance via recombination

Across TCGA cell cohorts, RNA activity of the Telomere maintenance via recombination pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRCA2, GEN1, and ZGRF1, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere maintenance via recombination activity versus BRCA2 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	BRCA2 →	+1.505	+0.115	<.001	<.001	3	17
BLOOD_Lymphoma	GEN1 →	+1.499	+0.099	<.001	<.001	3	17
BLOOD_Lymphoma	ZGRF1 →	+0.984	+0.071	<.001	<.001	3	16
OESOPHAGUS	WDHD1 →	+1.415	+0.085	.001	.006	3	16
BONE	POLQ →	+1.525	+0.085	<.001	.002	3	16
SOFT_TISSUE	PNN →	+1.138	+0.064	.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000722 vs BRCA2 — UPPER_AERODIGESTIVE_TRACT

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