Telomere maintenance via recombination

Across TCGA pan-cancer cohorts, RNA activity of the Telomere maintenance via recombination pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 14 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Telomere maintenance via recombination pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as READ and SKCM, show the opposite pattern, with higher activity associated with better survival.

ACC, KIRC, and BLCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.374	0.783	<.001	135	view →
KIRC	DFS	Quartile	All	0.454	0.706	<.001	129	view →
BLCA	DFS	Median	All	0.244	0.403	<.001	107	view →
LIHC	DFS	Median	All	0.430	0.630	<.001	90	view →
UVM	OS	Median	III,IV	0.332	0.793	.002	47	view →
KICH	OS	Tertile	II,III,IV	0.441	0.929	.010	42	view →
KIRP	OS	Median	All	0.513	0.827	<.001	38	view →
PRAD	DFS	Median	All	0.634	0.865	<.001	36	view →
MESO	OS	Tertile	III,IV	0.424	0.659	.009	35	view →
LUAD	DFS	Median	All	0.605	0.712	.002	25	view →
READ	OS	Median	IV	0.878	0.511	.008	22	view →
SKCM	DFS	Quartile	All	0.790	0.675	.006	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0000722–ACC (OS)

Open the ACC breakdown →