Resolution of meiotic recombination intermediates

Across TCGA patient cohorts, RNA activity of the Resolution of meiotic recombination intermediates pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FANCM, ZNF107, and CENPK, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Resolution of meiotic recombination intermediates activity versus FANCM in DLBC (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	FANCM →	+0.945	+0.062	<.001	<.001	3	33
DLBC	ZNF107 →	+1.900	+0.075	<.001	<.001	3	33
THYM	CENPK →	+1.585	+0.067	<.001	<.001	3	32
THYM	CEP128 →	+1.652	+0.056	<.001	<.001	3	32
DLBC	KNOP1 →	+0.796	+0.080	<.001	<.001	3	32
DLBC	CEP152 →	+1.331	+0.085	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000712 vs FANCM — DLBC

Explore this scatter interactively →