Resolution of meiotic recombination intermediates

Across TCGA cell cohorts, RNA activity of the Resolution of meiotic recombination intermediates pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACBD4, ZBTB6, and C11orf58, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACBD4 grouped by Resolution of meiotic recombination intermediates-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ACBD4 →	-1.243	-0.298	<.001	.004	3	4
LUNG_NSCLC_LUSC	ZBTB6 →	+0.733	+0.295	.005	.002	3	4
OESOPHAGUS	C11orf58 →	+0.691	+0.300	.003	.006	3	3
BREAST	BAIAP2L2 →	+1.383	+0.685	.005	.005	3	3
CNS	APOB →	-0.021	-0.604	.001	.003	3	3
OVARY	A4GALT →	+1.656	+0.226	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACBD4 by Resolution of meiotic recombination intermediates activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →