Resolution of meiotic recombination intermediates

Across TCGA cell cohorts, RNA activity of the Resolution of meiotic recombination intermediates pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOP2B, NDFIP1, and PGM2L1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Resolution of meiotic recombination intermediates activity versus TOP2B in LUNG_SCLC (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TOP2B →	+1.155	+0.300	.002	<.001	3	5
BLOOD_Leukemia	NDFIP1 →	-2.126	-0.312	<.001	<.001	3	5
KIDNEY	PGM2L1 →	+0.829	+0.276	.003	.006	3	4
OESOPHAGUS	FHL2 →	-2.403	-0.309	.001	.004	3	4
BLOOD_Leukemia	CYSTM1 →	-2.211	-0.272	<.001	<.001	3	4
LUNG_NSCLC_LUAD	OPLAH →	-1.426	-0.581	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000712 vs TOP2B — LUNG_SCLC

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