Box C/D snoRNP assembly

Across TCGA patient cohorts, RNA activity of the Box C/D snoRNP assembly pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAIP, EIF4EBP1, and VRK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Box C/D snoRNP assembly activity versus TRAIP in UCEC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAIP →	+0.773	+0.175	.002	<.001	3	5
UCEC	EIF4EBP1 →	+0.822	+0.155	.007	<.001	3	5
HNSC	VRK1 →	+0.887	+0.108	<.001	.002	3	4
PDAC	PTCD1 →	+0.198	+0.079	.005	.003	3	4
HNSC	DNA2 →	+0.702	+0.108	.001	.005	3	4
UCEC	FANCD2 →	+0.482	+0.123	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000492 vs TRAIP — UCEC

Explore this scatter interactively →